Consult with your healthcare provider if you notice your skin condition isn't improving or it worsens. There are some side effects associated with Silvadene usage, and they can range from mild to severe. If you have bothersome symptoms that persist, talk with your healthcare provider so that they can evaluate whether treatment with the drug is right for you.
Side effects may include the following:. Although many people can use this medication without significant problems, serious side effects can occur in some individuals.
If you develop any of the following symptoms, notify your healthcare provider as soon as possible:. Additionally, some people may develop leukopenia—a decrease in white blood cells WBCs —when using Silvadene cream for wounds and burns. Research shows that the onset of leukopenia tends to happen two to four days after treatment begins, with a recovery of the white blood cells occurring in two to three days after the initial drop or once the drug is discontinued.
If you have an increased sensitivity to silver sulfadiazine or the ingredients that make up the product, this medication may not be the right choice for you. Silvadene may be contraindicated in people with certain liver, kidney, or blood diseases. These conditions may affect how the drug is metabolized and eliminated from the body. In some instances, the drug can accumulate in the body, and you and your healthcare provider will need to weigh the benefits of staying on the treatment or discontinuing it.
Silvadene cream is not recommended for premature babies, newborn babies, or children 2 months of age or younger. Theoretically, drugs in the sulfonamide family may cause kernicterus—brain damage that results from excessive levels of bilirubin—in newborns, and therefore should only be used with extreme caution in people who are pregnant. When a patient starts a medication, an unfamiliar drug regimen sometimes feels overwhelming. This way, the healthcare provider can assess whether or not the medication is helping you heal and evaluate any additional symptoms and side effects you may be experiencing from treatment.
Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Silvadene cream. Topical antimicrobials for burn wound infections. Recent Pat Antiinfect Drug Discov. National Institue of Health. Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.
Int J Burns Trauma. A modern method of treatment: The role of silver dressings in promoting healing and preventing pathological scarring in patients with burn wounds. J Med Life. Food and Drug Administration. Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth.
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We and our partners process data to: Actively scan device characteristics for identification. I Accept Show Purposes. Table of Contents View All. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended.
Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine.
Make sure you tell your doctor if you have any other medical problems, especially:. It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To help clear up your skin or burn infection completely, keep using this medicine for the full time of treatment. You should keep using this medicine until the burned area has healed or is ready for skin grafting.
Do not miss any doses. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for any problems or unwanted effects that may be caused by this medicine.
If your skin infection or burn does not improve within a few days or weeks for more serious burns or burns over larger areas , or if it becomes worse, check with your doctor. Check with your doctor right away if you have the following symptoms while using this medicine: bleeding gums, cough or hoarseness, fever with or without chills, painful or difficult urination, sores, ulcers, or white spots on the lips or in the mouth, unusual bleeding, bruising, or weakness, or yellow skin or eyes.
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